BEBT-109, A PAN-MUTANT-SELECTIVE EGFR INHIBITOR WITH POTENT ANTITUMOR ACTIVITY IN EGFR-MUTANT NON-SMALL CELL LUNG CANCER

BEBT-109, a pan-mutant-selective EGFR inhibitor with potent antitumor activity in EGFR-mutant non-small cell lung cancer

EGFR mutation-positive NSCLC tumors are highly heterogeneous, therefore, exploring an agent simultaneously targeting multiple EGFR mutations may be valuable for clinical practice.Compared with osimertinib, BEBT-109 shows more sensitive and extensive antitumor activity in EGFR mutant NSCLC, while sparing wild-type EGFR cell lines.Meanwhile, unlike t

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Entropy Based Grey Relational Analysis Method for Multi-Attribute Decision Making under Single Valued Neutrosophic Assessments

In this paper we investigate multi-attribute decision making problem with single-valued neutrosophic attribute values.Crisp values are inadequate to model real life situation due to imprecise information frequently used in decision making process.Neutrosophic set is one pituitary gland in spanish such tool that can handle these situations.The ratin

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Detection of Wideband Signal Number Based on Bootstrap Resampling

Knowing source number correctly is the precondition for most spatial spectrum estimation methods; however, many snapshots are needed when we determine number of wideband signals.Therefore, a new method based on Bootstrap resampling is proposed pioneer ddj sz dimensions in this paper.First, signals are divided into some nonoverlapping subbands; appl

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